Credit: Original article published here.The incidence of pediatric chronic kidney disease (CKD) is low, and there are gaps in the quantity and quality of evidence informing clinical decision-making in pediatric CKD. Causes of CKD in children include congenital anomalies of the kidney and urinary tract (CAKUT) and acquired disease. Glomerular disease is the most common form of acquired pediatric CKD leading to kidney failure. Repeated episodes of acute kidney injury are also associated with increased risk for the development and progression of CKD in children. The most comprehensive data on the progression of CKD in children are from the Chronic Kidney Disease in Children (CKiD) study, an ongoing prospective cohort study that has enrolled more than 1000 children over three recruitment waves. According to Caroline A. Gluck, MD, and colleagues, CKiD data are limited by the relatively small sample size. The researchers conducted a study utilizing electronic heath record (EHR) data from a national multicenter pediatric network in the United States to identify a large cohort of children with CKD. The retrospective cohort study was designed to evaluate progression of CKD in the pediatric population and examine clinical risk factors for decline in kidney function. Results of the study were